Yes. Because Tylenol is not a blood thinner it is fine to take before surgery. Avoid aspirin and ibuprofen. Yes. Tylenol is not a blood thinner like Ibuprofen and Aspirin and can be taken before surgery. In general, it is safe to take Tylenol before surgery according to Drugs.com. Patients should let their doctors know of Tylenol use and dosage when scheduling a surgery. Tylenol (acetimitophen) is fine to take before surgery because it doesn't carry that same bleeding risk the NSAIDS and asprin have. BR WOW, i'm sorry, i could have done you harm, my doctor told me the exact opposite, i'm truly sorry i'm glad somebody corrected me. It is safe to take tylenol before surgery. Medications like aspirin, aleve/ibuprofen can interfere with blood clot formation, which may lead to excessive bleeding during surgery. Tylenol, no the other hand, is a pure Tylenol’s active ingredient is acetaminophen (or paracetamol). It is mainly used for pain and fever. Tylenol is a very old medication and is safe when taken at the recommended doses. IMPORTANT NOTICE. Patients who take products containing aspirin, vitamin E, or ibuprofen prior to surgery commonly have a marked increase in operative and post-operative bleeding. The following drugs contain aspirin or other products which can cause increased bleeding during surgery and should not be taken for 10 days prior to surgery. For relief of minor pain, you MAY take Tylenol (acetaminophen). My surgery is scheduled for Tuesday the 15th. I'm doing my one week pre-op diet. Couple.I am only able to take Tylenol cold which isn't getting rid of the stuffy nose.